BION - 1301

Anti-APRIL Monoclonal Antibody， potentially disease-modifying mechanism to deplete Gd-IgA1 (Hit 1) and prevent pathogenic immune complex formation (Hit 3).

Demonstrated durable reductions in mechanistic biomarkers and clinically meaningful proteinuria improvements in patients with IgAN .

• ●BION-1301 continues to demonstrate rapid and sustained reductions in mechanistic biomarkers in patients with IgAN, including free APRIL, IgA and Gd-IgA1 levels.
• ●BION-1301 demonstrated ~50% proteinuria reduction in patients with IgAN after three to six months of treatment, with ~70% reductions observed in six patients at one year and in two patients at 1.5 years of treatment.